Nine-man Lazio tumbled to a 4-1 defeat at Eintracht Frankfurt after two goals from Danny Da Costa and further strikes by Filip Kostic and Luka Jovic held the German club on top of Group H. Lazio had settled through Marco Parolo, but then had Dusan Basta and Joaquin Correa sent out before the hour mark. AC Milan slipped back after signing up early to send Olympiakos 3-1 to San Siro in the Europa League Group F.
Miguel Guerrero grabbed a guinea pig for the visitors only for the Italian giants to drive crazy with a jacket by Patrick Cutrone and one from Gonzalo Higuain. Bayer Leverkusen fought back from a goal down to seal a 4-2 victory over AEK Larnaca at BayArena. Bundesliga outfit swatted aside their poor domestic form to overtake Ivan Trickovsky's opening through strikes by Kai Havertz, Lucas Alario (two) and Julian Brandt, with Dimitris Raspas climbing a second for the Cypriots.
Leipzig announced the first victory in their Group B campaign by ruling 3-1 at Rosenborg with goals by Jean-Kevin Augustin, Ibrahima Konate and Matheus Cunha. Toni Sanabria, Giovani Lo Celso, and Cristian Tello bring Real Betis to a 3-0 win over Luxembourg minnows Dudelange, while Fredy Montero and Jovane Cabral pounced in the stopping time to give Sporting Lisbon a dramatic 2-1 comeback victory over Vorskla. Sevilla fell to a defeat 2-1 defeat in Krasnodar despite taking the lead through a separate goal of the Russian club.
Mauricio Pereyra was on target for the visitors 78 minutes into the game, before Tornike Okriashvili robbed the winner with two minutes to go. Santi Cazorla scored a final gasp penalty - his first goal in two years - as Villarreal saved a 3-3 draw at Spartak Moscow.
Zurich overwhelmed Ludogorets 1-0 through a late headline from Victor Palsson, while Alexander Kokorin pounced under similar circumstances to catapult Zenit St. Petersburg to victory over Slavia Prague with the same goal. Dynamo Zagreb won 2-0 at Anderlecht and Fenerbahce brushed aside Spartak Trnava, also 2-0. There were also victories to Astana, PAOK Salonika, Standard Liege, Malmo, FC Copenhagen, and Sarpsborg.